Partnering and Business Opportunities

Partnering and Business Opportunities:

 

If interested in any of these projects, please contact Mahima Agochiya, Business Development Manager of SPARK

 


Indication Modality Number Description
Anti-infective Antibiotic sk05029

Novel, less toxic aminoglycoside antibiotic based on new understanding of toxicity. Leads show broad-spectrum antimicrobial activity and substantially less ototoxicity and nephrotoxicity in animals.

Anti-infective Vaccine sk10121

Novel broadly-protective influenza vaccine. Currently optimizing protein folding and developing a cold-chain independent production scheme. Plan ferret testing within a year.

Cardiovascular Small Molecule sk09111

Novel target to treat heart failure through agonist activity. Proof-of-concept animal studies supported link between target signaling and cardiac function.

Cardiovascular, Hematology Diagnostic sk08078

Diagnostic predictor for risk of Kawasaki Disease in children for use in combination with in silico tool. Validating biomarkers in patient samples.

Dermatology Small Molecule sk07081

Small molecule inducer of melanin production/tanning response as therapy for xeroderma pigmentosum (XP), vitiligo, erythropoietic protoporphyria (EPP).

Gastroenterology, Pediatrics Diagnostic sk09113

A minimally invasive diagnostic method to detect intestinal mucosal injury related to inflammatory bowel diease or necrotizing enterocolitis. An ELISA based assay development is currently underway for selected biomarkers.

Gene Therapy Gene/Cell Therapy sk10134

Innovative platform to enhance Adeno-associated virus (AAV)-based gene therapy. Identified a host factor to improve AAV infection for all serotypes and cell types.

Hematology, Immunology Antibiotic, Gene/Cell Therapy sk08095

Therapeutic monoclonal antibody to treat acute graft versus host disease (GVHD) (orphan disease).

Metabolic Small Molecule sk08096

Small molecule inducer of beta cell regeneration for treatment of type 2 diabetes. Lead compound optimization on-going.

Metabolic Small Molecule sk08091

Novel targets for induction of brown fat from white fat to treat obesity. Preparing high-throughput screening to identify small molecule inhibitors.

Metabolic, Oncology Diagnostic sk08093

Inexpensive, point-of-care diagnostic to measure chemotherapy-induced hyperammonemia (“chemo brain”) and inborn errors of ammonia metabolism.

Oncology Small Molecule sk09105

Repurposed small molecule to prevent cancer emergence in patients with inherited BRCA-1 mutants (orphan disease). Establishing biomarkers and in consultation with FDA about trial endpoints. Good drug safety record, but never approved in USA.

Oncology Small Molecule sk10128

Topical formulation of a small molecule to prevent radiation-induced dermatitis and xerostomia

Platform Gene/Cell Therapy, Vaccine sk12158

Charge –Altering Releasable Transporters (CARTS): New materials enable a new platform technology for gene delivery, vaccinations, and cancer immunotherapy