Current SPARK Projects

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Indication Modality Title/Description
Anesthesia Small Molecule Safer Small Molecule Anesthetic For High Risk Patients , Infants, Elderly
Anti-infective, Global Health Device Spontaneously Formed Reactive Oxygen Species For Pathogen Disinfection
Anti-infective, Global Health Diagnostic Diagnostic For Prediction Of Severe Dengue
Anti-infective, Global Health Small Molecule Inhibitors For Enterovirus Infection
Anti-infective, Global Health Small Molecule Treatments for Drug-Resistant Tuberculosis
Anti-infective, Global Health, Rare/Orphan Disease Small Molecule Drugs For Treatment of Entamoeba and Naeglaria
Anti-infective Imaging Agent Molecular Imaging for Diagnosis of Bacterial Infections
Anti-infective, Child/Maternal Health, Global Health, Rare/Orphan Disease Biologic Synthetic Antimicrobial Peptoids For The Treatment Of Chronic Suppurative Otitis Media
Anti-infective, Child/Maternal Health, Global Health, Rare/Orphan Disease Biologic, Vaccine Nanoparticle To Treat Chronic Suppurative Otitis Media
Cardiology, Child/Maternal Health, Rare/Orphan Disease Imaging Agent Novel Optical Imaging Agent of Cardiac Conduction System for Use During Heart Surgery
Cardiovascular Small Molecule Novel Treatment for Heart Failure
Cardiology, Cardiovascular Biologic, Gene/Cell Therapy Mitochondrial biogenesis for cardiovascular disease
Child/Maternal Health, Rare/Orphan Disease, Rheumatology Diagnostic Immunophenotyping Of PANS To Inform Treatment
Child/Maternal Health, Pulmonary, Rare/Orphan Disease Small Molecule Inhaled Repurposed Drug To Treat Cystic Fibrosis
Child/Maternal Health, Platform Gene/Cell Therapy Platform To Enhance Therapeutic Gene Targeting
Child/Maternal Health, Platform Platform Technology For Delivery of DNA and RNA Therapies
Child/Maternal Health, Dermatology, Rare/Orphan Disease Small Molecule Topical Repurposed Drug For Epidermolysis Bullosa
Child/Maternal Health, Hematology, Rare/Orphan Disease Small Molecule Treatment for Diamond Blackfan Anemia
Child/Maternal Health, Neurology Prevention of post-hemorrhagic hydrocephalus in severe neonatal intraventricular hemorrhage
Child/Maternal Health, Opthalmology, Rare/Orphan Disease Biologic Bioactive Collagen Filler For Sutureless Corneal Tissue Reconstruction
Child/Maternal Health, Pregnancy, Rare/Orphan Disease Biologic Platelet Rich Plasma For Patients With Recurrent Implantation Failure
Child/Maternal Health, Congenital, Pulmonary, Rare/Orphan Disease Biologic CRISPRd upper airway stem cell for Cystic Fibrosis
Rare/Orphan Disease Gene/Cell Therapy Therapeutic transcriptome engineering
Child/Maternal Health, Congenital Gene/Cell Therapy Developing Integrases as next-generation Gene Therapies
Congenital, Dermatology Gene/Cell Therapy iPS-derived skin sheet product for dystrophic epidermolysis bullosa
Dermatology Small Molecule Therapeutic for Skin Cancers
Dermatology Small Molecule Therapeutic For Progressive Systemic Sclerosis
Endrocrinology, Immunology, Metabolic Biologic Developing Biologics for Diabetes
Endrocrinology Biologic Improved Insulin formulation for the Treatment of diabetes
Endrocrinology, Global Health Small Molecule Detection And Treatment Of Insulin Resistance
Gastroenterology, Metabolic Small Molecule Novel formulation to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis
Gastroenterology, Surgery Small Molecule Small molecule to prevent abdominal adhesion formation
Child/Maternal Health, Hematology Small Molecule Treatment of Diamond Blackfan Anemia
Gastroenterology, Hepatology, Metabolic Small Molecule Small molecule inhibition to prevent fibrosis in NASH
Hepatology Small Molecule Small Molecule To Prevent Progression Of Non Alcoholic Steatohepatitis
Immunology Diagnostic Profiling of immune responses to SARS-CoV-2 vaccination
Immunology Small Molecule Natural Product Flavanoids For Modulating Surgical Immune Response
Immunology Engineered Mesechymal Stem Cells For Immune Tolerance In Islet Transplant
Immunology MH-PSCs For Immune Suppression Free Transplant
Metabolic Small Molecule Small Molecule Activator To Treat Mitochondrial Disorders
Metabolic Small Molecule Small Molecule Inducer Of Beta Cell Regeneration
Neurology Small Molecule Novel Diagnostic/Therapeutic For Autism
Neurology, Rare/Orphan Disease Small Molecule Inhibitors Of RNA Lariat Debranching For ALS & HIV
Aging, Neurology Small Molecule Targeting Immune Function in Age-Associated diseases
Neurology Small Molecule Small Molecule Inhibitor For Treatment Of Neurodegenerative Disease
Neurology Small Molecule Small Molecule For The Treatment Of Parkinson’s Disease
Neurology Device Precision Care For Autism Through Wearable Artificial Intelligence
Neurology Imaging Agent PET Imaging Of Synapses In Schizophrenia
Neurology Small Molecule Open-label Pilot Study Of A Small Molecule for Children With Autism
Oncology Small Molecule Small Molecule for Cancers of Endodermal and Ectodermal Origin
Oncology Diagnostic Liquid biopsy-based Detection of Biomarkers for Early cancer detection
Oncology, Rare/Orphan Disease Small Molecule Small Molecule Activators For The Treatment Of Chronic Dry Mouth
Oncology, Rare/Orphan Disease Small Molecule Topical Treatment For Resistant Basal Cell Carcinoma
Oncology Imaging Agent Clinical Development and Commercialization of a Metabolic Imaging Agent for Glioblastoma
Oncology Small Molecule Targeted Therapy For Melanoma
Immunology, Metabolic, Oncology Biologic Therapeutic Antibodies for the Treatment of cancers associated with Obesity
Oncology Biologic Topical Biologic To Prevent Radiation-induced Oral Mucositis
Oncology Small Molecule Small Molecule To Restore A Global Immune Response Against Cancer
Oncology Small Molecule Small Molecule Inhibitors For Colorectal Cancer Stem Cells
Oncology Small Molecule Small Molecule For Chemotherapy-induced Pheripheral Nuerophathy
Oncology Small Molecule Selective Compounds For Triple-negative Breast Cancer
Child/Maternal Health, Immunology, Oncology Biologic, Gene/Cell Therapy, Small Molecule Drug-controlled CAR T cells for the treatment of pediatric leukemia
Oncology Small Molecule Novel Treatment For Kidney Cancer
Oncology Small Molecule Small Molecule Inhibition of Cell Proliferation through Disruption of Protein Interactions
Plastic Surgery Enhancing Fat Graft Retention Using Injectable Macroporous Matrices
Platform Diagnostic Multiplexed Pathogen Detection with Spectrally Encoded Beads
Platform Diagnostic Rapid detection of common cell-culture irregularities
Oncology, Pulmonary Biologic Antibody for treating Lung cancer and Fibrotic Lung diseases

Next Steps

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